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Opioid substitution therapy is a chance for a stable life for people who use drugs. It is a scientifically proven method of treating dependence, involving replacement of illegal opioids with controlled medical medications — methadone or buprenorphine. OST helps to: – reduce cravings for drugs – avoid withdrawal and overdoses – reduce the risk of HIV, hepatitis and other infections – improve mental and physical health – return to social life, work, family In this section, you will find information on where in Germany you can access substitution therapy — free of charge, confidentially and without stigma.